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True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase

Citation

Ghanem, A, True and false reversal of the elution order of barbiturates on a bonded cellulose-based chiral stationary phase, Journal of Chromatography A, 1132, (1-2) pp. 329-332. ISSN 0021-9673 (2006) [Refereed Article]


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DOI: doi:10.1016/j.chroma.2006.09.043

Abstract

A set of racemic N-alkylated barbiturates were investigated for their direct enantioselective HPLC separation on a new chiral stationary phase (CSP) containing cellulose tris(3,5-dimethylphenylcarabamate) immobilized onto silica gel (Chiralpak IB) and its coated version (Chiralcel OD). They were online detected by UV and optical rotation detectors to trace the elution order of their enantiomers. Surprisingly, examples of false and true reversal of the elution order of enantiomers of barbiturates were observed and reported.

Item Details

Item Type:Refereed Article
Keywords:Cellulose tris(3,5-dimethylphenylcarbamate); Chiralcel OD; Chiralpak IB; Enantioseparation; Elution order; HPLC; N-alkylated barbiturates
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ghanem, A (Dr Ashraf Ghanem)
ID Code:58322
Year Published:2006
Web of Science® Times Cited:22
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-09-25
Last Modified:2009-09-25
Downloads:0

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