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Enantioselective Toxicity and Carcinogenesis

Citation

Ali, I and Aboul-Enein, HY and Ghanem, A, Enantioselective Toxicity and Carcinogenesis, Current Pharmaceutical Analysis, 1, (1) pp. 109-125. ISSN 1573-4129 (2005) [Refereed Article]


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Copyright Statement

Copyright 2005 Bentham Science Publishers Ltd.

Official URL: http://www.bentham.org/

DOI: doi:10.2174/1573412052953328

Abstract

In a non-chiral environment, the enantiomers of a racemate possess the same physico-chemical properties but in the biological systems they possess different activities. One of the enantiomers may be more toxic or carcinogenic, and, therefore, the present data available on the toxicity and carcinogenesis of the racemic mixtures of these chiral pollutants are not reliable and need modification in terms of the enantioselective toxicity and carcinogenesis. It is essential to explore the enantioselective toxicity and carcinogenesis due to the different enantiomers of the chiral pollutants. The knowledge of the stereoselective metabolisms of the chiral pollutants may be useful for the treatment of cancer and other diseases. The enantioselective toxicity and carcinogenesis due to the chiral pesticides, pollutants and some drugs have been discussed in this review article.

Item Details

Item Type:Refereed Article
Keywords:polynuclear aromatic hydrocarbons; polychlorinted biphenyls; hexachlorocyclohexane; pest hazards; hepatocytes; pesticides
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ghanem, A (Dr Ashraf Ghanem)
ID Code:58320
Year Published:2005
Web of Science® Times Cited:37
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-09-25
Last Modified:2009-09-25
Downloads:1 View Download Statistics

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