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Enantioselective Toxicity and Carcinogenesis
Citation
Ali, I and Aboul-Enein, HY and Ghanem, A, Enantioselective Toxicity and Carcinogenesis, Current Pharmaceutical Analysis, 1, (1) pp. 109-125. ISSN 1573-4129 (2005) [Refereed Article]
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Copyright Statement
Copyright © 2005 Bentham Science Publishers Ltd.
Official URL: http://www.bentham.org/
DOI: doi:10.2174/1573412052953328
Abstract
In a non-chiral environment, the enantiomers of a racemate possess the same physico-chemical properties but in the biological systems they possess different activities. One of the enantiomers may be more toxic or carcinogenic, and, therefore, the present data available on the toxicity and carcinogenesis of the racemic mixtures of these chiral pollutants are not reliable and need modification in terms of the enantioselective toxicity and carcinogenesis. It is essential to explore the enantioselective toxicity and carcinogenesis due to the different enantiomers of the chiral pollutants. The knowledge of the stereoselective metabolisms of the chiral pollutants may be useful for the treatment of cancer and other diseases. The enantioselective toxicity and carcinogenesis due to the chiral pesticides, pollutants and some drugs have been discussed in this review article.
Item Details
Item Type: | Refereed Article |
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Keywords: | polynuclear aromatic hydrocarbons; polychlorinted biphenyls; hexachlorocyclohexane; pest hazards; hepatocytes; pesticides |
Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Ghanem, A (Dr Ashraf Ghanem) |
ID Code: | 58320 |
Year Published: | 2005 |
Web of Science® Times Cited: | 90 |
Deposited By: | Austn Centre for Research in Separation Science |
Deposited On: | 2009-09-25 |
Last Modified: | 2009-09-25 |
Downloads: | 1 View Download Statistics |
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