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Reversed Phase Liquid Chromatographic Method for the High-Throughput Analysis of Clopidogrel in Pharmaceutical Formulations Using a Monolithic Silica Column

Citation

Aboul-Enein, HY and Hoenen, H and Ghanem, A and Koll, M, Reversed Phase Liquid Chromatographic Method for the High-Throughput Analysis of Clopidogrel in Pharmaceutical Formulations Using a Monolithic Silica Column, Journal of Liquid Chromatography and Related Technologies, 28, (9) pp. 1357-1365. ISSN 1082-6076 (2005) [Refereed Article]


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Copyright Statement

The definitive published version is available online at: http://www.tandf.co.uk/journals

Official URL: http://www.tandf.co.uk/journals

DOI: doi:10.1081/JLC-200054835

Abstract

A high-throughput, high performance liquid chromatographic method was developed and validated for the determination of clopidogrel in pharmaceutical dosage forms. The analysis was performed at room temperature using a reversed phase monolithic silica column Chromolith Performance 18e (100 mmtimes4.6 mm I.D.). The mobile phase consisted of acetonitrile:phosphate buffer (50:50 v/v, pH 3.0) at a flow rate of 4.0 mL/min. The photodiode array detector was set at 235 nm. The developed method showed a good linear relationship in the concentration range from 1.0 to 40.0 g/mL with a correlation coefficient of 0.999. The limit of detection and limit of quantification were 0.97 g/mL and 3.52 g/mL, respectively.

Item Details

Item Type:Refereed Article
Keywords:HPLC; Monolithic column; Clopidogrel; Pharmaceutical analysis; High performance liquid chromatography
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ghanem, A (Dr Ashraf Ghanem)
ID Code:58311
Year Published:2005
Web of Science® Times Cited:12
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-09-25
Last Modified:2009-09-25
Downloads:0

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