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Lipase-catalyzed Irreversible Transesterification of Secondary Alcohols Using Isopropenyl Acetate
journal contribution
posted on 2023-05-17, 00:14 authored by Ghanem, A, Schurig, VAsymmetric acetylation of a set of secondary alcohols with the innocuous acyl donor isopropenyl acetate catalyzed by a lipase from Pseudomonas cepacia immobilized on ceramic particles (PSL-C) in toluene as organic medium afforded the chiral alcohols and the corresponding acetates in high enantiomeric excess (up to 99%). An effective baseline separation of the enantiomers of both substrate and product was performed in one analysis without derivatization using gas chromatography on a new chiral stationary phase (CSP) Chirasil-beta-Dex containing an undecamethylene spacer (C11-Chirasil-Dex).
History
Publication title
Monatshefte für Chemie / Chemical MonthlyVolume
134Issue
8Pagination
1151-1157ISSN
0026-9247Department/School
School of Natural SciencesPublisher
Springer-Verlag WienPlace of publication
Sachsenplatz 4-6, Po Box 89, Vienna, Austria, A-12Rights statement
The original publication is available at www.springerlink.comRepository Status
- Restricted