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Effects of atorvastatin on arterial stiffness in chronic kidney disease: a randomised controlled trial
Citation
Fassett, RG and Robertson, IK and Ball, MJ and Geraghty, DP and Sharman, JE and Coombes, JS, Effects of atorvastatin on arterial stiffness in chronic kidney disease: a randomised controlled trial, Journal of Atherosclerosis and Thrombosis, 17, (3) pp. 235-241. ISSN 1340-3478 (2010) [Refereed Article]
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DOI: doi:10.5551/jat.2683
Abstract
Background. Central pulse pressure and measures of arterial stiffness (augmentation index (AIx) and aortic pulse wave velocity (PWV)) predict morbidity and mortality in patients with stage 2-4 chronic kidney disease (CKD). Although statin therapy may be of vascular benefit in patients with CKD, the long-term effect of statins on central pulse pressure and arterial stiffness has not been assessed in this patient population.
Methods. We enrolled 37 patients with serum creatinine levels >1.36 mg/dl into a randomized, double blind trial. Patients were allocated to receive 10 mg of atorvastatin per day (19) or placebo (18) for three years. Aortic PWV, AIx, estimated central and brachial blood pressures and were determined every nine months.
Results. At baseline, there were no significant differences in aortic PWV, AIx, central or brachial blood pressures between atorvastatin-treated and placebo-treated patients. During the trial, aortic PWV significantly (P=0.021) increased in placebo-treated, but not (P=0.17) in atorvastatin-treated patients (0.51„b0.88 vs. 0.18„b0.45 m/sec/yr; P=0.20). This represented a 65% (but not statistically significant) slowing of the rate of increase in aortic stiffness. There were no significant changes between groups in the rate of change of AIx (atorvastatin -0.08„b5.27 vs. placebo -0.15„b5.08 %/yr, P=0.97) or central pulse pressure (atorvastatin -2.52„b6.61 vs. placebo -0.45„b6.37 mm Hg /yr P=0.53).
Conclusion. In patients with CKD arterial stiffness measured by aortic PWV showed a significant increase over time in placebo-treated patients but not in atorvastatin-treated patients.
(Trial registration: ACTRN012605000693628)
Item Details
Item Type: | Refereed Article |
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Keywords: | Active Australia; Self-Reported Health; Renal Disease, METmins/week |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Nephrology and urology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Robertson, IK (Dr Iain Robertson) |
UTAS Author: | Ball, MJ (Professor Madeleine Ball) |
UTAS Author: | Geraghty, DP (Professor Dominic Geraghty) |
UTAS Author: | Sharman, JE (Professor James Sharman) |
ID Code: | 58287 |
Year Published: | 2010 |
Web of Science® Times Cited: | 40 |
Deposited By: | Health Sciences A |
Deposited On: | 2009-09-23 |
Last Modified: | 2011-04-05 |
Downloads: | 2 View Download Statistics |
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