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The 1984 Tasmanian Insulin-Treated Diabetes-Mellitus Prevalence Cohort - An 8 and a Half Year Mortality Follow-Up Investigation
journal contribution
posted on 2023-05-16, 09:54 authored by Riley, MD, McCarty, DJ, Couper, DJ, Humphrey, ARG, Terry DwyerTerry Dwyer, Zimmet, PTotal mortality and underlying cause of death were examined in a population-based prevalence cohort (n = 1232) of Tasmanians with insulin-treated diabetes mellitus. Eight and a half years after the establishment of the registry, the cause of death based on death certificate information was determined for the overall cohort and for three classification groups of insulin-treated diabetes: Group A - childhood-onset IDDM cases; Group B - adult-onset IDDM cases; and Group C - adult-onset insulin-treated NIDDM cases. A total of 378 deaths occurred, providing an overall SMR of 2.2 (95% CI 2.0-2.4) compared to the Tasmanian population. Diabetic females experienced a higher SMR (2.6, 95% CI 2.3-3.0) than diabetic males (1.9, 95% Cl 1.6-2.2). The all-cause SMRs for the diabetic classification groups were 4.6 (95% CI 3.4-6.1) in Group A, 1.8 (95% CI 1.5-2.1) in Group B, and 2.2 (95% CI 1.9-2.6) in Group C. After adjusting for age, gender and duration of diabetes, the mortality in Group C was significantly higher compared to Group B (odds ratio 1.6, 95% CI 1.2-2.3). This study indicates that people with childhood-onset IDDM experience 4.6 times the death rate compared to the Tasmanian population and that the excess mortality is most pronounced in females.
History
Publication title
Diabetes Research and Clinical PracticeVolume
29Pagination
27-35ISSN
0168-8227Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Sci Ireland LtdPlace of publication
Customer Relations Manager, Bay 15, Shannon Industrial Estate Co, Clare, IrelandRepository Status
- Restricted