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Direct Enantioselective HPLC Monitoring of Lipase-Catalyzed Kinetic Resolution of 2-Phenoxy Propionic Acid in Non-Standard Organic Solvents
Citation
Ghanem, A and El-Behairy, F and Al-Ahdal, M, Direct Enantioselective HPLC Monitoring of Lipase-Catalyzed Kinetic Resolution of 2-Phenoxy Propionic Acid in Non-Standard Organic Solvents, Chromatographia, 65, (11-12) pp. 681-686. ISSN 0009-5893 (2007) [Refereed Article]
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Copyright Statement
The original publication is available at www.springerlink.com
Official URL: http://www.springerlink.com
DOI: doi:10.1365/s10337-007-0216-8
Abstract
In this work, a direct enantioselective HPLC monitoring system is developed. The system consists of an HPLC equipped with an immobilized cellulose-based chiral stationary phase Chiralpak IB, UV and a polarimetric detector in series. The developed system is used in the direct monitoring of the enantioselectivity of lipase-catalyzed enantioselective esterification of 2-phenoxy propionic acid of which the (R)-enantiomer is a precursor of the (R)-2-(p-hydroxyphenoxy)propionic acid known as an important intermediate in synthesizing aryloxyphenoxypropionic acid based agrochemicals. The versatility of the biocatalyzed reaction in chiral separation to access to both enantiomers of racemic 2-phenoxy propionic acid is demonstrated. The solvent versatility of the immobilized chiral stationary phase used in the direct monitoring of such reaction in non-standard HPLC solvent is shown.
Item Details
Item Type: | Refereed Article |
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Keywords: | Column liquid chromatography - Enantioselective separation - Kinetic resolution - Phenoxy propionic acid - Lipases |
Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Ghanem, A (Dr Ashraf Ghanem) |
ID Code: | 57767 |
Year Published: | 2007 |
Web of Science® Times Cited: | 4 |
Deposited By: | Austn Centre for Research in Separation Science |
Deposited On: | 2009-08-12 |
Last Modified: | 2009-08-13 |
Downloads: | 0 |
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