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Direct Enantioselective HPLC Monitoring of Lipase-Catalyzed Kinetic Resolution of 2-Phenoxy Propionic Acid in Non-Standard Organic Solvents

Citation

Ghanem, A and El-Behairy, F and Al-Ahdal, M, Direct Enantioselective HPLC Monitoring of Lipase-Catalyzed Kinetic Resolution of 2-Phenoxy Propionic Acid in Non-Standard Organic Solvents, Chromatographia, 65, (11-12) pp. 681-686. ISSN 0009-5893 (2007) [Refereed Article]


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The original publication is available at www.springerlink.com

Official URL: http://www.springerlink.com

DOI: doi:10.1365/s10337-007-0216-8

Abstract

In this work, a direct enantioselective HPLC monitoring system is developed. The system consists of an HPLC equipped with an immobilized cellulose-based chiral stationary phase Chiralpak IB, UV and a polarimetric detector in series. The developed system is used in the direct monitoring of the enantioselectivity of lipase-catalyzed enantioselective esterification of 2-phenoxy propionic acid of which the (R)-enantiomer is a precursor of the (R)-2-(p-hydroxyphenoxy)propionic acid known as an important intermediate in synthesizing aryloxyphenoxypropionic acid based agrochemicals. The versatility of the biocatalyzed reaction in chiral separation to access to both enantiomers of racemic 2-phenoxy propionic acid is demonstrated. The solvent versatility of the immobilized chiral stationary phase used in the direct monitoring of such reaction in non-standard HPLC solvent is shown.

Item Details

Item Type:Refereed Article
Keywords:Column liquid chromatography - Enantioselective separation - Kinetic resolution - Phenoxy propionic acid - Lipases
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ghanem, A (Dr Ashraf Ghanem)
ID Code:57767
Year Published:2007
Web of Science® Times Cited:4
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-08-12
Last Modified:2009-08-13
Downloads:0

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