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Peracetylated â-cyclodextrin as additive in enzymatic reactions: enhanced reaction rate and enantiomeric ratio in lipase-catalyzed transesterifications in organic solvents

Citation

Ghanem, A and Schurig, V, Peracetylated a-cyclodextrin as additive in enzymatic reactions: enhanced reaction rate and enantiomeric ratio in lipase-catalyzed transesterifications in organic solvents, Tetrahedron: Asymmetry, 12, (19) pp. 2761-2766. ISSN 0957-4166 (2001) [Refereed Article]


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DOI: doi:10.1016/S0957-4166(01)00482-7

Abstract

Peracetylated â-cyclodextrin has been employed as a macrocyclic additive to enhance the enantiomeric ratio E and reaction rate in Pseudomonas cepacia lipase (PSL)-catalyzed enantioselective transesterification of 1-(2-furyl)ethanol in organic solvents. The beneficial action of the cyclodextrin used as a regulator of lipase was tentatively interpreted as increasing the conformational flexibility of the enzyme and undergoing host–guest complexation with the product, thereby preventing product inhibition and leading to an enhancement of the enantiomeric ratio E and the reaction rate. The effect of the organic solvent on the present cyclodextrin-mediated enzymatic transesterification has been studied.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Organic Chemistry
Research Field:Organic Green Chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
UTAS Author:Ghanem, A (Dr Ashraf Ghanem)
ID Code:57747
Year Published:2001
Web of Science® Times Cited:33
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-08-12
Last Modified:2009-08-13
Downloads:0

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