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Lipase-catalyzed irreversible transesterification of 1-(2-furyl)ethanol using isopropenyl acetate
Citation
Ghanem, A and Schurig, V, Lipase-catalyzed irreversible transesterification of 1-(2-furyl)ethanol using isopropenyl acetate, Chirality, 13, (2) pp. 118-123. ISSN 0899-0042 (2001) [Refereed Article]
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The definitive published version is available online at: http://interscience.wiley.com
Official URL: http://interscience.wiley.com
DOI: doi:10.1002/1520-636X(2001)13:2<118::AID-CHIR1007>3.0.CO;2-Q
Abstract
Asymmetric acetylation of racemic 1-(2-furyl)ethanol with the innocuous acyl donor isopropenyl acetate catalyzed by lipases in organic media afforded the chiral alcohol and acetate in high enantiomeric excess (up to 99%). The effect of molecular sieves as well as organic solvents on the kinetic resolution were studied. An effective separation of the enantiomers of both substrate and product was performed using gas chromatography on the chiral stationary phase heptakis-(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)--cyclodextrin.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | enzymatic kinetic resolution; enantiomeric excess; gas chromatography; lipase; heptakis-(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)--cyclodextrin |
| Research Division: | Chemical Sciences |
| Research Group: | Organic chemistry |
| Research Field: | Organic green chemistry |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the chemical sciences |
| UTAS Author: | Ghanem, A (Dr Ashraf Ghanem) |
| ID Code: | 57746 |
| Year Published: | 2001 |
| Web of Science® Times Cited: | 30 |
| Deposited By: | Austn Centre for Research in Separation Science |
| Deposited On: | 2009-08-12 |
| Last Modified: | 2009-08-13 |
| Downloads: | 0 |
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