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Lipase-catalyzed irreversible transesterification of 1-(2-furyl)ethanol using isopropenyl acetate

journal contribution
posted on 2023-05-16, 23:59 authored by Ghanem, A, Schurig, V
Asymmetric acetylation of racemic 1-(2-furyl)ethanol with the innocuous acyl donor isopropenyl acetate catalyzed by lipases in organic media afforded the chiral alcohol and acetate in high enantiomeric excess (up to 99%). The effect of molecular sieves as well as organic solvents on the kinetic resolution were studied. An effective separation of the enantiomers of both substrate and product was performed using gas chromatography on the chiral stationary phase heptakis-(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)--cyclodextrin.

History

Publication title

Chirality

Volume

13

Pagination

118-123

ISSN

0899-0042

Department/School

School of Natural Sciences

Publisher

Wiley

Place of publication

Germany

Rights statement

The definitive published version is available online at: http://interscience.wiley.com

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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