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Naturally occurring genetic variation affects Drosophila photoreceptor determination
Citation
Polaczyk, P and Gasperini, RJ and Gibson, G, Naturally occurring genetic variation affects Drosophila photoreceptor determination, Development Genes and Evolution, 207, (7) pp. 462-470. ISSN 0949-944X (1998) [Refereed Article]
DOI: doi:10.1007/s004270050137
Abstract
The signal transduction pathway controlling determination of the identity of the R7 photoreceptor in the Drosophila eye is shown to harbor high levels of naturally occurring genetic variation. The number of ectopic R7 cells induced by the dosage-sensitive Sev(S11.1) transgene that encodes a mildly activated form of the Sevenless tyrosine kinase receptor is highly sensitive to the wild-type genetic background. Phenotypes range from complete suppression to massive overproduction of photoreceptors that exceeds reported effects of known single gene modifiers, and are to some extent sex-dependent. Signaling from the dominant gain-of-function Drosophila Epidermal Growth Factor Receptor (DER-Ellipse) mutations is also sensitive to the genetic backgrounds, but there is no correlation with the effects on Sev(S11.1). This implies that different genes and/or alleles modify the two activated receptor genotypes. The evolutionary significance of the existence of high levels of genetic variation in the absence of normal phenotypic variation is discussed.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biological Sciences |
Research Group: | Genetics |
Research Field: | Gene mapping |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Gasperini, RJ (Dr Rob Gasperini) |
ID Code: | 57739 |
Year Published: | 1998 |
Web of Science® Times Cited: | 57 |
Deposited By: | Anatomy and Physiology |
Deposited On: | 2009-08-12 |
Last Modified: | 2011-10-03 |
Downloads: | 0 |
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