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Reduction of abstinence induced withdrawal and craving using nicotine replacement therapy
Citation
Shiffman, S and Ferguson, SG and Gwaltney, C and Balabanis, M and Shadel, W, Reduction of abstinence induced withdrawal and craving using nicotine replacement therapy, Psychopharmacology (Berl), 184, (3-4) pp. 637-44. ISSN 0033-3158 (2006) [Refereed Article]
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Copyright Statement
The final publication is available at http://www.springerlink.com
Official URL: http://www.springerlink.com
DOI: doi:10.1007/s00213-005-0184-3
Abstract
Rationale
Decreasing withdrawal and craving during smoking cessation is a major aim of cessation medications. Prior studies have shown that Nicotine Replacement Therapy (NRT) decreases withdrawal symptom severity but have relied on retrospective reports and lacked robust measures of baseline symptoms or symptoms during unmedicated abstinence.
Objectives and methods
We tested the effect of high-dose (35 mg) nicotine patch on withdrawal and craving during abstinence using real-time assessment with electronic diaries during ad libitum smoking, a brief period of experimentally directed trial abstinence, and the first 3 days of cessation. Subjects were 324 smokers randomized to high-dose nicotine patches or placebo.
Results
Treatment with active patches reduced withdrawal and craving during cessation and completely eliminated deprivation-related changes in affect or concentration.
Conclusion
High-dose NRT reduces withdrawal symptoms and craving and can eliminate some symptoms entirely.
Item Details
Item Type: | Refereed Article |
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Keywords: | Transdermal nicotine replacement - Withdrawal - Smoking cessation |
Research Division: | Health Sciences |
Research Group: | Public health |
Research Field: | Preventative health care |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Public health (excl. specific population health) not elsewhere classified |
UTAS Author: | Ferguson, SG (Professor Stuart Ferguson) |
ID Code: | 57265 |
Year Published: | 2006 |
Web of Science® Times Cited: | 25 |
Deposited By: | Pharmacy |
Deposited On: | 2009-07-01 |
Last Modified: | 2011-05-05 |
Downloads: | 3 View Download Statistics |
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