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Reduction of abstinence induced withdrawal and craving using nicotine replacement therapy


Shiffman, S and Ferguson, SG and Gwaltney, C and Balabanis, M and Shadel, W, Reduction of abstinence induced withdrawal and craving using nicotine replacement therapy, Psychopharmacology (Berl), 184, (3-4) pp. 637-44. ISSN 0033-3158 (2006) [Refereed Article]

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DOI: doi:10.1007/s00213-005-0184-3


Rationale Decreasing withdrawal and craving during smoking cessation is a major aim of cessation medications. Prior studies have shown that Nicotine Replacement Therapy (NRT) decreases withdrawal symptom severity but have relied on retrospective reports and lacked robust measures of baseline symptoms or symptoms during unmedicated abstinence. Objectives and methods We tested the effect of high-dose (35 mg) nicotine patch on withdrawal and craving during abstinence using real-time assessment with electronic diaries during ad libitum smoking, a brief period of experimentally directed trial abstinence, and the first 3 days of cessation. Subjects were 324 smokers randomized to high-dose nicotine patches or placebo. Results Treatment with active patches reduced withdrawal and craving during cessation and completely eliminated deprivation-related changes in affect or concentration. Conclusion High-dose NRT reduces withdrawal symptoms and craving and can eliminate some symptoms entirely.

Item Details

Item Type:Refereed Article
Keywords:Transdermal nicotine replacement - Withdrawal - Smoking cessation
Research Division:Health Sciences
Research Group:Public health
Research Field:Preventative health care
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Ferguson, SG (Professor Stuart Ferguson)
ID Code:57265
Year Published:2006
Web of Science® Times Cited:24
Deposited By:Pharmacy
Deposited On:2009-07-01
Last Modified:2011-05-05
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