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Reduction of abstinence induced withdrawal and craving using nicotine replacement therapy
journal contribution
posted on 2023-05-16, 23:49 authored by Shiffman, S, Stuart FergusonStuart Ferguson, Gwaltney, C, Balabanis, M, Shadel, WRationale Decreasing withdrawal and craving during smoking cessation is a major aim of cessation medications. Prior studies have shown that Nicotine Replacement Therapy (NRT) decreases withdrawal symptom severity but have relied on retrospective reports and lacked robust measures of baseline symptoms or symptoms during unmedicated abstinence. Objectives and methods We tested the effect of high-dose (35 mg) nicotine patch on withdrawal and craving during abstinence using real-time assessment with electronic diaries during ad libitum smoking, a brief period of experimentally directed trial abstinence, and the first 3 days of cessation. Subjects were 324 smokers randomized to high-dose nicotine patches or placebo. Results Treatment with active patches reduced withdrawal and craving during cessation and completely eliminated deprivation-related changes in affect or concentration. Conclusion High-dose NRT reduces withdrawal symptoms and craving and can eliminate some symptoms entirely.
History
Publication title
Psychopharmacology (Berl)Volume
184Issue
3-4Pagination
637-44ISSN
0033-3158Department/School
School of Pharmacy and PharmacologyPublisher
SpringerPlace of publication
GermanyRights statement
The final publication is available at http://www.springerlink.comRepository Status
- Restricted