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Nicotine replacement therapy (NRT) repeatedly has been shown to improve smoking treatment outcome. The major mechanism posited for this improvement in outcome is that NRT reduces nicotine craving and withdrawal. The authors tested this hypothesized mechanism of action using real-time data on craving and withdrawal, collected by ecological momentary assessments administered on a palm-top computer. Smokers (N = 324) were randomized to receive either active high-dose (35 mg) 24-hr patches or placebo. Increases in positive affect and decreases in craving, negative affect, and attention disturbance severity were related to lower risk of lapsing. Although NRT treatment did significantly decrease withdrawal and craving severity, these reductions only partially accounted for NRT's impact on time to first lapse: The results from a mediation analysis showed that the hazard ratio for NRT, when controlling for withdrawal and craving severity, was only a third to a half lower than the uncontrolled hazard ratio for NRT alone. This suggests that other mechanisms for the effectiveness of NRT need to be examined. © 2006 APA, all rights reserved.

Item Type:	Refereed Article
Keywords:	smoking cessation
Research Division:	Medical and Health Sciences
Research Group:	Public Health and Health Services
Research Field:	Preventive Medicine
Objective Division:	Health
Objective Group:	Public Health (excl. Specific Population Health)
Objective Field:	Substance Abuse
Author:	Ferguson, SG (Associate Professor Stuart Ferguson)
ID Code:	57259
Year Published:	2006
Web of Science® Times Cited:	83
Deposited By:	Pharmacy
Deposited On:	2009-07-01
Last Modified:	2011-05-13
Downloads:	5 View Download Statistics