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Counter-flow electrokinetic supercharging for the determination of non-steroidal anti-inflammatory drugs in water samples

Citation

Dawod, M and Breadmore, MC and Guijt, RM and Haddad, PR, Counter-flow electrokinetic supercharging for the determination of non-steroidal anti-inflammatory drugs in water samples, Journal of Chromatography A, 1216, (15) pp. 3380-3386. ISSN 0021-9673 (2009) [Refereed Article]


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The definitive version is available at http://www.sciencedirect.com

Official URL: http://www.elsevier.com

DOI: doi:10.1016/j.chroma.2009.02.014

Abstract

Electrokinetic supercharging (EKS) has been used in the last few years as a powerful tool for separation and on-line preconcentration of different types of analytes. We have developed a valuable modification for EKS system, namely counter-flow EKS (CF-EKS) and applied it for the separation and on-line preconcentration of seven non-steroidal anti-inflammatory drugs (NSAIDs) in water samples. In CF-EKS, a hydrodynamic counter-flow is applied during electrokinetic injection of the analytes within the EKS system. This counter-flow minimises the introduction of the sample matrix into the capillary, allowing longer injections to be performed. Careful choice of the optimum counter-flow as well as the optimum injection voltage allowed the sensitivity to be enhanced by 11,800-fold, giving limits of detection (LODs) of 10.7–47.0 ng/L for the selected NSAIDs. The developed method was validated and then applied for the determination of the studied NSAIDs in drinking water as well as wastewater samples from Hobart city.

Item Details

Item Type:Refereed Article
Keywords:Non-steroidal anti-inflammatory drugs; Capillary electrophoresis; Counter-flow; Electrokinetic supercharging; Water samples; Stacking
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Dawod, M (Mr Mohamed Dawod)
Author:Breadmore, MC (Professor Michael Breadmore)
Author:Guijt, RM (Dr Rosanne Guijt)
Author:Haddad, PR (Professor Paul Haddad)
ID Code:56052
Year Published:2009
Web of Science® Times Cited:42
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-03-23
Last Modified:2010-04-08
Downloads:0

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