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ERM Proteins Regulate Growth Cone Responses to Sema3A

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posted on 2023-05-16, 23:20 authored by Mintz, CD, Carcea, I, McNickle, DG, Tracey DicksonTracey Dickson, Ge, Y, Salton, SRJ, Benson, DL
Axonal growth cones initiate and sustain directed growth in response to cues in their environment. A variety of events such as receptor internalization, kinase activation, and actin rearrangement can be stimulated by guidance cues and are essential for mediating targeted growth cone behavior. Surprisingly little is known about how such disparate actions are coordinated. Our data suggest that ezrin, radixin, and moesin (ERMs), a family of highly homologous, multifunctional proteins may be able to coordinate growth cone responses to the guidance cue Semaphorin 3A (Sema3A). We show that active ERMs concentrate asymmetrically in neocortical growth cones, are rapidly and transiently inactivated by Sema3A, and are required for Sema3A-mediated growth cone collapse and guidance. The FERM domain of active ERMs regulates internalization of the Sema3A receptor, Npn1, and its coreceptor, L1CAM, while the ERM C-terminal domain binds and caps F-actin. Our data support a model in which ERMs can coordinate membrane and actin dynamics in response to Sema3A. © 2008 Wiley-Liss, Inc.

History

Publication title

The Journal of Comparative Neurology

Volume

510

Issue

4

Pagination

351-366

ISSN

0021-9967

Department/School

Menzies Institute for Medical Research

Publisher

John Wiley & Sons Inc

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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