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Adiposity Gain During Childhood, ACE I/D Polymorphisms and Metabolic Outcomes

Citation

Ponsonby, AL and Blizzard, CL and Pezic, A and Cochrane, JA and Ellis, JA and Morley, R and Dickinson, JL and Sale, MM and Richards, SM and Dwyer, T, Adiposity Gain During Childhood, ACE I/D Polymorphisms and Metabolic Outcomes, Obesity, 16, (9) pp. 2141-2147. ISSN 1930-7381 (2008) [Refereed Article]

DOI: doi:10.1038/oby.2008.302

Abstract

We aimed to (i) determine the relative importance of childhood gain in upper body adiposity for insulin resistance (IR) and triglyceridemia (TG); (ii) examine whether the associations between adiposity and metabolic indices were more evident in those with the ACE DD genotype. We examined a birth cohort study of 292 children with measures in the neonatal period (day 4) including subscapular and triceps skinfolds; repeat skinfold measures at age 8, cardiorespiratory (CR) fitness, IR by the homeostasis model assessment (HOMA) equation (HOMA-IR) and serum triglyceride (TG) concentrations and measures of ACE I/D gene variants. A multiple linear regression analysis incorporating a life course approach was undertaken. Childhood gain in upper body adiposity was positively associated with HOMA-IR and TG independently of neonatal skinfolds (P 0.02). The magnitude of these associations was higher among those of the ACE DD genotype. For example, subscapular skinfold gain was not strongly associated with HOMA-IR or TG among those with II or ID genotype (b 0.03, P 0.05; b 0.02, P 0.18 respectively) but was positively associated among those with the DD genotype (b 0.11, P 0.001; b 0.08, P 0.003); difference in effect P 0.05; P 0.01 respectively. Upper body fat accumulation during childhood was positively associated with HOMA-IR and TG independently of neonatal skinfolds. Further, the stronger associations for those with the ACE DD genotype is consistent with randomised controlled trial findings that ACE inhibition is associated with a reduced risk of developing type 2 diabetes. Further work is required to confirm and extend these findings. © 2008 The Obesity Society.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Aboriginal and Torres Strait Islander Health
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Blizzard, CL (Associate Professor Leigh Blizzard)
Author:Cochrane, JA (Mrs Jennifer Cochrane)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
Author:Sale, MM (Dr Michele Sale)
Author:Richards, SM (Dr Stephen Richards)
Author:Dwyer, T (Professor Terry Dwyer)
ID Code:55680
Year Published:2008
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-03-12
Last Modified:2014-11-24
Downloads:0

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