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Association between birth weight and adolescent systolic blood pressure in a caucasian birth cohort differs according to skin type, CRH promoter or 11β-HSD2 genotype

Citation

Dwyer, T and Blizzard, L and Patterson, B and Ponsonby, A-L and Martin, K and Quinn, S and Sale, MM and Richards, SM and Morley, R and Rich, S and Dickinson, JL, Association between birth weight and adolescent systolic blood pressure in a caucasian birth cohort differs according to skin type, CRH promoter or 11β-HSD2 genotype, Archives of Disease in Childhood, 93, (9) pp. 760-767. ISSN 0003-9888 (2008) [Refereed Article]

DOI: doi:10.1136/adc.2007.129122

Abstract

Objective: To examine whether the inverse association between birth weight and blood pressure varies by skin pigmentation and/or related genotypes.

Study design: 671 children from a predominantly caucasian birth cohort were followed-up to adolescence (mean (SD) age 14.4 (0.64)).

Methods: Data on birth weight, socioeconomic status, maternal antenatal smoking, adolescent blood pressure and polymorphisms of candidate genes were obtained and analysed by multiple linear regression.

Results: An increase in birth weight of 1 kg was associated with an non-significant difference in adolescent systolic blood pressure of –0.53 mm Hg (95% CI –1.72 to 0.66) per kg after adjustment for child age and cohort entry criteria. The inverse association between birth weight and systolic blood pressure was stronger for those with darker skin (⩾ 2% melanin) (difference in effect, p = 0.02), those with more copies of the C allele of corticotropin-releasing hormone (CRH) +T1273C (p =  0.06), and those with more copies of the short (⩽ 236 bp) form of the 11β-HSD2{CA}nrepeat microsatellite (p =  0.03).

Conclusions: These findings add to the evidence that cortisol-related pathways may account for at least part of the observed birth weight–blood pressure associations.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Public Health and Health Services not elsewhere classified
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Specific Population Health (excl. Indigenous Health) not elsewhere classified
Author:Dwyer, T (Professor Terry Dwyer)
Author:Blizzard, L (Professor Leigh Blizzard)
Author:Patterson, B (Dr Briony Patterson)
Author:Ponsonby, A-L (Professor Anne Ponsonby)
Author:Martin, K (Dr Kara Martin)
Author:Quinn, S (Dr Stephen Quinn)
Author:Sale, MM (Dr Michele Sale)
Author:Richards, SM (Dr Stephen Richards)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
ID Code:54453
Year Published:2008
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-02-23
Last Modified:2015-07-31
Downloads:0

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