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Assessment of Thrombin Generation: Useful or Hype?


Adams, MJ, Assessment of Thrombin Generation: Useful or Hype?, Seminars in Thrombosis and Haemostasis, 35, (1) pp. 104-110. ISSN 0094-6176 (2009) [Refereed Article]

DOI: doi:10.1055/s-0029-1214153


Thrombin plays an important role in hemostasis through its multiple functions across blood coagulation, platelet activation, and fibrinolysis. The measurement of thrombin generation is therefore viewed as a potentially useful test that could be applied to the screening, monitoring, and/or diagnosis of hemostatic abnormalities. Indeed, advances in thrombin generation assays have created significant interest and debate as to whether they may provide amore physiologically relevant testing system than do traditional coagulation tests. A variety of thrombin generation assays, including commercially available systems, have been investigated for their correlation with hypocoagulable and hypercoagulable states. Although there is an extensive body of literature that has investigated the application of thrombin generation assays, some limitations remain. These include poor standardization of reagents and methods and a lack of large prospective studies that demonstrate clear relationships between thrombin generation with bleeding and thrombosis phenotypes, as well as with monitoring anticoagulation. Whether thrombin generation assays become more "useful" than "hype" will require well-designed, large, prospective multicenter trials using standardized methods. Copyright © 2009 by Thieme Medical Publishers, Inc.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Adams, MJ (Dr Murray Adams)
ID Code:53929
Year Published:2009
Web of Science® Times Cited:31
Deposited By:Health Sciences A
Deposited On:2009-01-28
Last Modified:2010-04-13

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