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Prediction equations for single breath diffusing capacity (DLCO) in a middle aged caucasian population

Citation

Thompson, BT and Johns, DP and Bailey, M and Raven, J and Walters, EH and Abramson, MJ, Prediction equations for single breath diffusing capacity (DLCO) in a middle aged caucasian population, Thorax, 63, (10) pp. 889-893. ISSN 0040-6376 (2008) [Refereed Article]

DOI: doi:10.1136/thx.2007.091959

Abstract

Background: There are many reference equations for the measurement of single breath carbon monoxide diffusing capacity of the lung (Tlco). However, the testing methodologies vary and there are no well documented studies that have developed reference equations for Tlco and alveolar volume (Va) in middle aged and older populations. Aims: (1) Develop reference equations for Tlco in a middle aged population using the current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines; (2) compare the equations with those commonly used in laboratories around the world. Methods: Healthy subjects (498 male and 474 female) aged 45-71 years were recruited as part of a larger epidemiological study. All participants completed a respiratory questionnaire and had spirometry and single breath Tlco (corrected for haemoglobin) measurements following ATS/ERS guidelines. Results: Mean age was 58 years for males and 57 years for females. For males, factors that predicted Tlco were: height, age, age x height interaction and being an exsmoker. For females, factors that predicted Tlco were: height, age, weight and an age x height interaction. Conclusion: We have described new prediction equations for Tlco in a middle aged population that require validation in other populations.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Johns, DP (Associate Professor David Johns)
Author:Walters, EH (Professor Haydn Walters)
ID Code:53902
Year Published:2008
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-01-20
Last Modified:2009-05-02
Downloads:0

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