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Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals

Citation

Roche, JR and Blache, D and Kay, JK and Miller, Dale and Sheahan, AJ and Miller, DW, Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals , Nutrition Research Reviews, 21, (2) pp. 207-234. ISSN 0954-4224 (2008) [Refereed Article]

DOI: doi:10.1017/S0954422408138744

Abstract

The central nervous system undertakes the homeostatic role of sensing nutrient intake and body reserves, integrating the information, and regulating energy intake and/or energy expenditure. Few tasks regulated by the brain hold greater survival value, particularly important in farmed ruminant species, where the demands of pregnancy, lactation and/or growth are not easily met by often bulky plant-based and sometimes nutrient-sparse diets. Information regarding metabolic state can be transmitted to the appetite control centres of the brain by a diverse array of signals, such as stimulation of the vagus nerve, or metabolic 'feedback' factors derived from the pituitary gland, adipose tissue, stomach/abomasum, intestine, pancreas and/or muscle. These signals act directly on the neurons located in the arcuate nucleus of the medio-basal hypothalamus, a key integration, and hunger (orexigenic) and satiety (anorexigenic) control centre of the brain. Interest in human obesity and associated disorders has fuelled considerable research effort in this area, resulting in increased understanding of chronic and acute factors influencing feed intake. In recent years, research has demonstrated that these results have relevance to animal production, with genetic selection for production found to affect orexigenic hormones, feeding found to reduce the concentration of acute controllers of orexigenic signals, and exogenous administration of orexigenic hormones (i.e. growth hormone or ghrelin) reportedly increasing DM intake in ruminant animals as well as single-stomached species. The current state of knowledge on factors influencing the hypothalamic orexigenic and anorexigenic control centres is reviewed, particularly as it relates to domesticated ruminant animals, and potential avenues for future research are identified.

Item Details

Item Type:Refereed Article
Research Division:Agricultural and Veterinary Sciences
Research Group:Animal Production
Research Field:Animal Nutrition
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Dairy Cattle
Author:Roche, JR (Dr John Roche)
Author:Miller, Dale (Dr Dale Miller)
ID Code:53831
Year Published:2008
Web of Science® Times Cited:54
Deposited By:Agricultural Science
Deposited On:2009-01-12
Last Modified:2009-04-06
Downloads:0

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