eCite Digital Repository
Plasma concentrations of fentanyl with subcutaneous infusion in palliative care patients
Citation
Miller, RS and Peterson, GM and Abbott, F and Maddocks, I and Parker, D and McLean, SR, Plasma concentrations of fentanyl with subcutaneous infusion in palliative care patients, British Journal of Clinical Pharmacology, 40, (6) pp. 553 - 556. ISSN 0306-5251 (1995) [Refereed Article]
![]() | PDF Restricted - Request a copy 610Kb |
Copyright Statement
The definitive published version is available online at: http://onlinelibrary.wiley.com/
Official URL: http://onlinelibrary.wiley.com/
Abstract
Plasma concentrations of fentanyl were measured by g.c. in 20 patients (median age: 75 years and range: 54-86 years; eight females) in palliative care receiving the drug by continuous s.c. infusion (median rate: 1200 micrograms day-1 and range: 100-5000 micrograms day-1). 2. The infusion rate was significantly related to the duration of therapy (Spearman rho = 0.56, P < 0.05). The total steady-state plasma concentrations of fentanyl ranged between 0.1 and 9 ng ml-1, with a median of 1 ng ml-1. The unbound fraction of fentanyl in the plasma ranged from 17.8 to 44.4%, with a median value of 33.6%. Infusion rates and both total and unbound plasma concentrations of fentanyl were correlated (Spearman rho = 0.92, P < 0.05 in each case). Even with standardization for dosage, there was an eightfold variation in total plasma concentrations and 3.5-fold variation in unbound plasma concentrations of fentanyl. 3. There is considerable inter-patient variability in the pharmacokinetics of fentanyl with s.c. infusion in the palliative care setting, which necessitates careful titration of dosage according to individual clinical response.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Clinical pharmacology and therapeutics |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Miller, RS (Mrs Rachel Susan Miller) |
UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
UTAS Author: | McLean, SR (Professor Stuart McLean) |
ID Code: | 5377 |
Year Published: | 1995 |
Web of Science® Times Cited: | 12 |
Deposited By: | Pharmacy |
Deposited On: | 1995-08-01 |
Last Modified: | 2011-06-02 |
Downloads: | 0 |
Repository Staff Only: item control page