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N-acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity

Citation

Cooley, MA and Chhabra, SR and Williams, P, N-acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity, Chemistry & Biology, 15, (11) pp. 1141-1147. ISSN 1074-5521 (2008) [Contribution to Refereed Journal]

DOI: doi:10.1016/j.chembiol.2008.10.010

Abstract

Communication through quorum sensing (QS) enables bacterial populations to coordinate their behavior. Recent work on N-acylhomoserine lactone-mediated QS has revealed that some soil bacteria exploit host-derived substrates to generate an alternative N-substituted homoserine lactone. New light has also been shed on the mechanism by which N-(3-oxo-dodecanoyl)-l-homoserine lactone modulates host inflammatory signaling pathways to promote bacterial survival. © 2008 Elsevier Ltd. All rights reserved.

Item Details

Item Type:Contribution to Refereed Journal
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Cooley, MA (Associate Professor Margaret Cooley)
ID Code:53381
Year Published:2008
Web of Science® Times Cited:57
Deposited By:Menzies Institute for Medical Research
Deposited On:2008-12-04
Last Modified:2008-12-04
Downloads:0

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