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Cycloleucine-induced vacuolation of myeline is associated with inhibition of protein methylation

Citation

Small, DH and Carnegie, PR and Anderson, RM, Cycloleucine-induced vacuolation of myeline is associated with inhibition of protein methylation, Neuroscience Letters, 21, (3) pp. 287-292. ISSN 0304-3940 (1981) [Refereed Article]

DOI: doi:10.1016/0304-3940(81)90218-4

Abstract

Chickens injected with cycloleucine developed vacuolation of myelin similar to that seen in humans with vitamin B12 deficiency. Cycloleucine, an inhibitor of the formation of S-adenosylmethionine, decreased the incorporation of methyl groups into methylarginine in myelin basic protein in vivo. The need for methylcobalamin for the conversion of homocysteine to methionine and the requirement that myelin basic protein be methylated, offer a rational explanation for the myelin lesions observed in cases of vitamin B12 deficiency where there is increasing evidence that methyl-, rather than adenosylcobalamin is required to prevent dysmyelination. © 1981.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Neurochemistry
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
ID Code:52866
Year Published:1981
Web of Science® Times Cited:40
Deposited By:Menzies Institute for Medical Research
Deposited On:2008-10-02
Last Modified:2008-10-02
Downloads:0

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