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The Heritability of Corneal Hysteresis and Ocular Pulse Amplitude
Citation
Carbonaro, F and Andrew, T and Mackey, DA and Spector, TD and Hammond, CJ, The Heritability of Corneal Hysteresis and Ocular Pulse Amplitude, Ophthalmology, 115, (9) pp. 1545-1549. ISSN 0161-6420 (2008) [Refereed Article]
DOI: doi:10.1016/j.optha.2008.02.011
Abstract
Purpose: To examine the roles of genetic and environmental factors in corneal hysteresis and ocular pulse amplitude by performing a classic twin study. Design: Cross-sectional twin study. Participants and/or Controls: Two hundred sixty-four twin pairs: 135 monozygotic (MZ) and 129 dizygotic (DZ). Methods: Corneal hysteresis was measured using the Reichert Ocular Response Analyzer (ORA; Reichert, Buffalo, NY), and ocular pulse amplitude was measured using the Pascal Dynamic Contour Tonometer (DCT; Swiss Microtechnology AG, Port, Switzerland). Main Outcome Measures: Contribution of genetic and environmental effects on corneal hysteresis and OPA among MZ and DZ twins. Results: The mean corneal hysteresis was10.24±1.54 mmHg and the mean ocular pulse amplitude was 2.88±0.97 mmHg. The MZ correlations were higher than DZ for both corneal hysteresis and ocular pulse amplitude (correlation coefficients, 0.75:0.42 and 0.59:0.32 for MZ:DZ twins, respectively). Modeling suggested heritability of corneal hysteresis of 0.77 (95% confidence interval [CI], 0.70-0.82), with the remaining proportion of variance because of individual environmental effects of 0.23 (95% CI, 0.18-0.30). For ocular pulse amplitude, the heritability was 0.62 (95% CI, 0.51-0.70), with the remaining proportion of variance the result of individual environmental effects of 0.38 (95% CI, 0.30-0.49). Conclusions: This study demonstrated that additive genetic influences explained most of the individual differences in corneal hysteresis and ocular pulse amplitude among these twins. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. © 2008 American Academy of Ophthalmology.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Ophthalmology and optometry |
| Research Field: | Ophthalmology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Mackey, DA (Professor David Mackey) |
| ID Code: | 52819 |
| Year Published: | 2008 |
| Web of Science® Times Cited: | 41 |
| Deposited By: | Medicine |
| Deposited On: | 2008-09-22 |
| Last Modified: | 2009-03-17 |
| Downloads: | 0 |
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