Ding, C and Parameswaran, V and Cicuttini, F and Burgess, JR and Zhai, G and Quinn, S and Jones, G, Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian Older Adult Cohort (TASOAC) study, Annals of the Rheumatic Diseases, 67, (9) pp. 1256-1261. ISSN 0003-4967 (2008) [Refereed Article]
Copyright 2008 BMJ Publishing Group Ltd & European League Against Rheumatism
Objective: To describe the associations between leptin, body composition, sex and knee cartilage volume/defects in older adults.
Methods: A cross-sectional sample of 190 randomly selected subjects (mean 63 years, range 52–78, 48% female) were studied. Knee cartilage volume and defects were determined using T1-weighted fat saturation MRI. Serum leptin levels were measured by radioimmunoassay. Fat and lean mass were measured by dual energy x ray absorptiometry (DXA). Body mass index (BMI) was calculated.
Results: In multivariable analysis, serum levels of leptin were negatively associated with total cartilage volume (β: 2541 mm3/log transformed unit, 95% CI 2861 to 2221) but not with prevalent knee cartilage defects. BMI was negatively associated with cartilage volume after adjustment for total lean mass and positively with prevalent knee cartilage defects. However, the association between BMI and cartilage volume disappeared after adjustment for leptin while the association between BMI and cartilage defects remained unchanged. Lastly, sex differences in total cartilage volume decreased substantially after adjustment for leptin (R2 from 51% to 30%).
Conclusions: This cross-sectional study suggests cartilage volume loss with obesity and female sex is related to leptin and, thus, is hormonally mediated in older adults. By contrast, obesity related knee focal cartilage defects may be more related to non-hormonal factors.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Specific Population Health (excl. Indigenous Health)|
|Objective Field:||Health Related to Ageing|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Author:||Burgess, JR (Professor John Burgess)|
|Author:||Zhai, G (Dr Guangju Zhai)|
|Author:||Quinn, S (Dr Stephen Quinn)|
|Author:||Jones, G (Professor Graeme Jones)|
|Funding Support:||National Health and Medical Research Council (302204)|
|Web of Science® Times Cited:||48|
|Deposited By:||Menzies Institute for Medical Research|
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