Fitzgerald, LM and Thomson, RJ and Polanowski, AM and Patterson, B and McKay, JD and Stankovich, J and Dickinson, JL, Sequence variants of α-methylacyl-CoA racemase are associated with prostate cancer risk: A replication study in an ethnically homogeneous population, The Prostate, 68, (13) pp. 1373-1379. ISSN 0270-4137 (2008) [Refereed Article]
Background: Examination of variants of the α-methylacyl-CoA racemase (AMACR) gene, as genetic contributors to prostate cancer risk, has been of considerable interest given the gene's recently established role as a diagnostic biomarker for prostate cancer.
Methods: The AMACR gene variants, M9V and D175G, were genotyped in a familial dataset comprising 127 cases and in a second sporadic prostate cancer dataset comprising 414 cases and 319 controls. Genotype-disease associations were examined employing the MQLS test and unconditional logistic regression. Differences in allele frequencies were examined using the Fisher's exact test. Association between the AMACR haplotypes and prostate cancer risk was also investigated using haplo.score.
Results: Significant evidence for association with prostate cancer risk for both the M9V and D175G variants was observed in the Tasmanian prostate cancer dataset. Whilst this association remained significant, it was diminished when relatedness amongst the familial prostate cancer cases was considered.
Conclusion: This study, performed in a relatively genetically homogenous Tasmanian population, provides further evidence for a significant association between variants within the AMACR gene and prostate cancer risk. Risk was found to be more significantly associated with AMACR gene variants in sporadic compared to familial prostate cancer cases. These findings again highlight that genetic heterogeneity in the study population should be considered when examining genetic risk factors in prostate cancer.
|Item Type:||Refereed Article|
|Keywords:||prostate cancer, susceptibility gene variant|
|Research Division:||Medical and Health Sciences|
|Research Group:||Oncology and Carcinogenesis|
|Research Field:||Oncology and Carcinogenesis not elsewhere classified|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cancer and Related Disorders|
|UTAS Author:||Fitzgerald, LM (Dr Liesel Fitzgerald)|
|UTAS Author:||Thomson, RJ (Dr Russell Thomson)|
|UTAS Author:||Polanowski, AM (Ms Andrea Polanowski)|
|UTAS Author:||Patterson, B (Dr Briony Patterson)|
|UTAS Author:||Stankovich, J (Dr Jim Stankovich)|
|UTAS Author:||Dickinson, JL (Professor Joanne Dickinson)|
|Web of Science® Times Cited:||11|
|Deposited By:||Menzies Institute for Medical Research|
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