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Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin

Citation

Powell, KL and Kyi, M and Reid, CA and Paradiso, L and D'Abaco, GM and Kaye, AH and Foote, SJ and O'Brien, TJ, Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin, Neurobiology of Disease, 31, (2) pp. 261-265. ISSN 0969-9961 (2008) [Refereed Article]

DOI: doi:10.1016/j.nbd.2008.04.012

Abstract

Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and duration of absence seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Furthermore, mutations in this gene result in the Stargazer mouse that displays an absence epilepsy phenotype. GAERS stargazin mRNA expression is increased 1.8 fold in the somatosensory cortex and by 1.3 fold in the thalamus. The changes were present before and after the onset of absence seizures indicating that increases are not a secondary consequence of the seizures. Stargazin protein expression was also significantly increased in the somatosensory cortex after the onset of spontaneous seizures. The results are of significant importance beyond the GAERS model, as they are the first to show that an increase in stargazin expression may be pro-epileptic. © 2008 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene Expression (incl. Microarray and other genome-wide approaches)
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
UTAS Author:Foote, SJ (Professor Simon Foote)
ID Code:52436
Year Published:2008
Funding Support:National Health and Medical Research Council (406640)
Web of Science® Times Cited:14
Deposited By:Menzies Institute for Medical Research
Deposited On:2008-08-01
Last Modified:2009-05-02
Downloads:0

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