Wray_J_Neuroimmunol.pdf (180.74 kB)
CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
journal contribution
posted on 2023-05-16, 21:51 authored by Wray, BN, Jim Stankovich, Whittock, LD, Dwyer, T, Ponsonby, AL, Ingrid van der MeiIngrid van der Mei, Bruce TaylorBruce Taylor, Joanne DickinsonJoanne Dickinson, Simon James FooteSimon James Foote, McMorran, BJMultiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype. © 2008 Elsevier B.V. All rights reserved.
History
Publication title
Journal of NeuroimmunologyVolume
196Issue
1-2Pagination
139-142ISSN
0165-5728Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier BVPlace of publication
NetherlandsRepository Status
- Restricted