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CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population

Citation

Wray, BN and Stankovich, J and Whittock, LD and Dwyer, T and Ponsonby, AL and Van der Mei, IAF and Taylor, BVM and Dickinson, JL and Foote, SJ and McMorran, BJ, CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population, Journal of Neuroimmunology, 196, (1-2) pp. 139-142. ISSN 0165-5728 (2008) [Refereed Article]

DOI: doi:10.1016/j.jneuroim.2008.02.001

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype. © 2008 Elsevier B.V. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Neurogenetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Wray, BN (Mr Brad Wray)
UTAS Author:Stankovich, J (Dr Jim Stankovich)
UTAS Author:Whittock, LD (Dr Lucy Whittock)
UTAS Author:Van der Mei, IAF (Associate Professor Ingrid van der Mei)
UTAS Author:Taylor, BVM (Professor Bruce Taylor)
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
UTAS Author:Foote, SJ (Professor Simon Foote)
UTAS Author:McMorran, BJ (Associate Professor Brendan McMorran)
ID Code:52364
Year Published:2008
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2008-07-01
Last Modified:2014-12-17
Downloads:0

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