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Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips

journal contribution
posted on 2023-05-16, 21:26 authored by Michael BreadmoreMichael Breadmore
Poor sensitivity is considered to be one of the major limitations of electrophoretic separation methods, particularly when compared to traditional liquid chromatographic techniques. To address this issue, various in-line preconcentration techniques have been developed over the past 15 years, ranging in power and complexity, and there are now a number of well understood approaches routinely capable of providing a 10 000- to 100 000-fold increase in sensitivity, as well as several that can be pushed above a million. Furthermore, these have been achieved with particularly troublesome and often difficult samples, such as those having high salinity from a biological or environmental origin. This review will discuss the most common methods for improving the sensitivity of CE, CEC and microchip version of these, with particular attention to those approaches developed over the last five years. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

History

Publication title

Electrophoresis

Volume

28

Issue

1-2

Pagination

254-281

ISSN

0173-0835

Department/School

School of Natural Sciences

Publisher

Wiley-VCH

Place of publication

Weinheim

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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