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Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips
Citation
Breadmore, MC, Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips, Electrophoresis, 28, (1-2) pp. 254-281. ISSN 0173-0835 (2007) [Refereed Article]
DOI: doi:10.1002/elps.200600463
Abstract
Poor sensitivity is considered to be one of the major limitations of electrophoretic separation methods, particularly when compared to traditional liquid chromatographic techniques. To address this issue, various in-line preconcentration techniques have been developed over the past 15 years, ranging in power and complexity, and there are now a number of well understood approaches routinely capable of providing a 10 000- to 100 000-fold increase in sensitivity, as well as several that can be pushed above a million. Furthermore, these have been achieved with particularly troublesome and often difficult samples, such as those having high salinity from a biological or environmental origin. This review will discuss the most common methods for improving the sensitivity of CE, CEC and microchip version of these, with particular attention to those approaches developed over the last five years. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Item Details
Item Type: | Refereed Article |
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Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Breadmore, MC (Professor Michael Breadmore) |
ID Code: | 51273 |
Year Published: | 2007 |
Web of Science® Times Cited: | 176 |
Deposited By: | Chemistry |
Deposited On: | 2007-08-01 |
Last Modified: | 2008-05-01 |
Downloads: | 0 |
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