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Long-term assessment of oxcarbazepine in a naturalistic setting: a retrospective study

Citation

Seneviratne, U and D'Souza, W and Cook, M, Long-term assessment of oxcarbazepine in a naturalistic setting: a retrospective study, Acta Neurologica Scandinavica, 117, (5) pp. 367-369. ISSN 0001-6314 (2008) [Refereed Article]

DOI: doi:10.1111/j.1600-0404.2007.00951.x

Abstract

Background - New antiepileptics seem to be better tolerated by patients. The retention rate of an antiepileptic would be a useful indicator of its practical usefulness. Aims - To assess the long-term outcome of oxcarbazepine (OXC) in a naturalistic setting by determining the retention rate. Methods - This is a retrospective study. All epilepsy patients treated with OXC at a tertiary care epilepsy center during a period of 3.5 years were included in this study. Retention rates of OXC at 1 and 3 years were estimated for each cohort group using Kaplan-Meier estimates and corresponding 95% confidence intervals. Results - A total of 98 patients were studied. OXC was used as monotherapy in 14 (14.3%) and as add-on therapy in 84 (85.7%). The mean daily dose was 947 ± 492 mg and 60% received ≤900 mg/day. Using the Kaplan-Meier survival analysis, the retention rates of OXC at 1 and 3 years were estimated to be 0.853 (0.749-0.956) and 0.737 (0.570-0.904), respectively. Conclusions - OXC is well tolerated by patients as both monotherapy and add-on therapy. © 2007 The Authors.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Health and Support Services
Objective Field:Evaluation of Health Outcomes
Author:D'Souza, W (Dr D'Souza)
ID Code:50597
Year Published:2008 (online first 2007)
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2017-05-25
Downloads:0

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