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Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: A longitudinal study

Citation

Burgess, JA and Walters, EH and Byrnes, GB and Matheson, MC and Jenkins, MA and Wharton, CL and Johns, DP and Abramson, MJ and Hopper, JL and Dharmage, SC, Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: A longitudinal study, Journal of Allergy and Clinical Immunology, 120, (4) pp. 863-869. ISSN 0091-6749 (2007) [Refereed Article]

DOI: doi:10.1016/j.jaci.2007.07.020

Abstract

Background: The association between allergic rhinitis and asthma is well documented, but the temporal sequence of this association has not been closely examined. Objective: We sought to assess the associations between childhood allergic rhinitis and (1) asthma incidence from preadolescence to middle age and (2) asthma persistence to middle age. Methods: Data were gathered from the 1968, 1974, and 2004 surveys of the Tasmanian Asthma Study. Cox regression was used to examine the association between childhood allergic rhinitis and asthma incidence in preadolescence, adolescence, and adult life. Binomial regression was used to examine the association between childhood allergic rhinitis and asthma beginning before the age of 7 years and persisting at age 44 years. Results: Childhood allergic rhinitis was associated with a significant 2- to 7-fold increased risk of incident asthma in preadolescence, adolescence, or adult life. Childhood allergic rhinitis was associated with a 3-fold increased risk of childhood asthma persisting compared with remitting by middle age. Conclusions: Childhood allergic rhinitis increased the likelihood of new-onset asthma after childhood and the likelihood of having persisting asthma from childhood into middle age. Clinical implications: Asthma burden in later life might be reduced by more aggressive treatment of allergic rhinitis in early life. © 2007 American Academy of Allergy, Asthma & Immunology.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Walters, EH (Professor Haydn Walters)
Author:Johns, DP (Associate Professor David Johns)
ID Code:50509
Year Published:2007
Web of Science® Times Cited:103
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2009-08-19
Downloads:0

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