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Obesity, Insulin Resistance, and Capillary Recruitment


Rattigan, S and Bussey, CT and Ross, RM and Richards, SM, Obesity, Insulin Resistance, and Capillary Recruitment, Microcirculation, 14, (4-5) pp. 299-309. ISSN 1073-9688 (2007) [Refereed Article]

DOI: doi:10.1080/10739680701282796


Objective: Insulin has vascular actions within the skeletal muscle microcirculation (capillary recruitment) that enhance its own access and that of glucose to the muscle cells. Obesity and insulin resistance are associated with dysregulated vascular function within muscle and a loss of insulin-mediated capillary recruitment. Furthermore, agents that impair insulin's vascular actions to recruit capillaries lead to acute insulin resistance in terms of muscle glucose uptake. Together these data suggest a strong connection between the loss of insulin-mediated capillary recruitment and the development of insulin resistance. This review examines the mechanisms involved in insulin-mediated capillary recruitment and the vascular defects associated with obesity and insulin resistance that may impair the capillary recruiting process. Understanding the mechanisms of insulin-mediated capillary recruitment and its impairment may lead to new treatment avenues to prevent the progression of obesity to diabetes.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Rattigan, S (Professor Stephen Rattigan)
UTAS Author:Bussey, CT (Miss Carol Bussey)
UTAS Author:Ross, RM (Dr Renee Ross)
UTAS Author:Richards, SM (Dr Stephen Richards)
ID Code:50402
Year Published:2007
Web of Science® Times Cited:24
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2016-02-18

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