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Systemic corticosteroids in chronic obstructive pulmonary disease: An overview of Cochrane systematic reviews

Citation

Wood-Baker, R and Walters, JAE and Walters, EH, Systemic corticosteroids in chronic obstructive pulmonary disease: An overview of Cochrane systematic reviews, Respiratory Medicine, 101, (3) pp. 371-377. ISSN 0954-6111 (2007) [Refereed Article]

DOI: doi:10.1016/j.rmed.2006.07.013

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by symptoms of cough, sputum and breathlessness, which become worse during acute exacerbations. The airway inflammation associated with COPD has led to trials of the effect of systemic corticosteroids in COPD assessed in two Cochrane systematic reviews. In stable COPD, compared with placebo, oral corticosteroid treatment increased mean FEV 1 by 53 ml and mean 12-min walking distance by 29 m, but at an increased risk of any drug-related adverse event (OR 7.8). In acute exacerbations, oral corticosteroid treatment decreased the chance of treatment failure (OR 0.48), improved mean FEV 1 at 72 h by 140 ml and improved arterial blood gases, but increased the risk of drug-related adverse events (OR 2.3). Thus, treatment of stable and acute exacerbations of COPD with systemic corticosteroids results in statistically significant average benefits, but at an increased risk of adverse events. In stable COPD, there is little support for the use of systemic corticosteroid treatment, as data on long-term outcomes are lacking. For acute exacerbations, the evidence to support the use of systemic corticosteroids is stronger, but further research is required to define the optimum dose, route and duration. © 2006 Elsevier Ltd. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Wood-Baker, R (Professor Richard Wood-Baker)
Author:Walters, JAE (Dr Julia Walters)
Author:Walters, EH (Professor Haydn Walters)
ID Code:50292
Year Published:2007
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2010-05-19
Downloads:0

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