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MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis

Citation

Dombrecht, B and Xue, GP and Sprague, SJ and Kirkegaard, JA and Ross, JJ and Reid, JB and Fitt, GP and Sewelam, N and Schenk, PM and Manners, JM and Kazan, K, MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis, The Plant Cell, 19, (7) pp. 2225-2245. ISSN 1040-4651 (2007) [Refereed Article]

DOI: doi:10.1105/tpc.106.048017

Abstract

The Arabidopsis thaliana basic helix-loop-helix Leu zipper transcription factor (TF) MYC2/JIN1 differentially regulates jasmonate (JA)-responsive pathogen defense (e.g., PDF1.2) and wound response (e.g., VSP) genes. In this study, genome-wide transcriptional profiling of wild type and mutant myc2/jin1 plants followed by functional analyses has revealed new roles for MYC2 in the modulation of diverse JA functions. We found that MYC2 negatively regulates Trp and Trp-derived secondary metabolism such as indole glucosinolate biosynthesis during JA signaling. Furthermore, MYC2 positively regulates JA-mediated resistance to insect pests, such as Helicoverpa armigera, and tolerance to oxidative stress, possibly via enhanced ascorbate redox cycling and flavonoid biosynthesis. Analyses of MYC2 cis binding elements and expression of MYC2-regulated genes in T-DNA insertion lines of a subset of MYC2-regulated TFs suggested that MYC2 might modulate JA responses via differential regulation of an intermediate spectrum of TFs with activating or repressing roles in JA signaling. MYC2 also negatively regulates its own expression, and this may be one of the mechanisms used in fine-tuning JA signaling. Overall, these results provide new insights into the function of MYC2 and the transcriptional coordination of the JA signaling pathway. © 2007 American Society of Plant Biologists.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene Expression (incl. Microarray and other genome-wide approaches)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Ross, JJ (Associate Professor John Ross)
Author:Reid, JB (Professor Jim Reid)
ID Code:50270
Year Published:2007
Web of Science® Times Cited:408
Deposited By:Plant Science
Deposited On:2007-08-01
Last Modified:2009-05-07
Downloads:0

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