Background: The metabolic syndrome is a risk factor for cardiovascular diseases, which have been linked to Alzheimer disease. However, a link between Alzheimer disease and the metabolic syndrome has not yet been established. Objective: To investigate the relationship between the metabolic syndrome and Alzheimer disease. Design, Setting, and Participants: Case-control study of 50 consecutive patients diagnosed with probable Alzheimer disease from the Memory Disorders Clinics, Launceston, Australia, and Bristol, England, and 75 cognitively normal controls. Main Outcome Measures: The odds ratio of the metabolic syndrome as defined by the National Cholesterol Education Program Adult Treatment Panel III. Results: Compared with controls, patients with Alzheimer disease had a significantly larger mean waist circumference, higher mean plasma concentrations of triglycerides and glucose, and a lower mean plasma concentration of high-density lipoprotein cholesterol, but they had lower mean systolic blood pressure. The metabolic syndrome was associated with Alzheimer disease (odds ratio, 3.2; 95% confidence interval, 1.2-8.4; P=.02), and this association was strengthened when the hypertension component was excluded (odds ratio, 7.0; 95% confidence interval, 2.7-18.3; P<.001). All of the analyses were adjusted for age, sex, and location. Conclusions: This study suggests that Alzheimer disease is associated with the metabolic syndrome. This could have implications for the prevention and treatment of Alzheimer disease. ©2007 American Medical Association. All rights reserved.

Item Type:	Refereed Article
Research Division:	Medical and Health Sciences
Research Group:	Clinical Sciences
Research Field:	Geriatrics and Gerontology
Objective Division:	Health
Objective Group:	Specific Population Health (excl. Indigenous Health)
Objective Field:	Health Related to Ageing
Author:	Razay, G (Dr George Razay)
Author:	Vreugdenhil, AJ (Associate Professor Anthea Vreugdenhil)
ID Code:	50155
Year Published:	2007
Web of Science® Times Cited:	140
Deposited By:	Sociology and Social Work
Deposited On:	2007-08-01
Last Modified:	2009-09-10
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