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A prospective study of urinary electrolytes and bone turnover in adolescent males

Citation

Jones, G and Dwyer, T and Hynes, K and Parameswaran, V and Udayan, R and Greenaway, T, A prospective study of urinary electrolytes and bone turnover in adolescent males, Clinical Nutrition, 26, (5) pp. 619-623. ISSN 0261-5614 (2007) [Refereed Article]

DOI: doi:10.1016/j.clnu.2007.06.014

Abstract

Background & aims: The role of excessive salt on bone metabolism in children is uncertain. The aim of this 6-week prospective study was to describe the association between urinary electrolytes and bone turnover markers in a convenience sample of adolescent boys (N=136, mean age 16 yr). Methods: Urinary electrolytes (sodium, potassium, calcium and magnesium) were assessed on spot overnight urines on three occasions to minimise regression dilution bias. Bone turnover was assessed by bone specific alkaline phosphatase (BAP) and urinary pyridinoline (PYR) at baseline and follow up. Results: In multivariate analysis, urinary sodium (but not other electrolytes) was positively associated with both PYR and BAP both before and after taking short-term growth into account (both p<0.05) and explained 3-6% of the variation in bone turnover markers. Urinary sodium was associated with urinary magnesium (r=+0.26, p<0.05) but only weakly with calcium (r=+0.18, p=0.08). Urinary potassium was significantly associated with urinary magnesium (r=-0.24, p<0.05). Conclusion: High urinary sodium (which largely reflects dietary sodium intake in our location) results in a high bone turnover state in adolescent boys which is most likely detrimental for bone. Other urinary electrolytes are not related to bone turnover but may influence bone via other pathways. © 2007 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
Author:Dwyer, T (Professor Terry Dwyer)
Author:Hynes, K (Dr Kristen Hynes)
ID Code:49967
Year Published:2007
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2008-05-14
Downloads:0

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