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Prevalence and Clinical Features of Common LRRK2 Mutations in Australians with Parkinson's Disease

Citation

Huang, Y and Halliday, GM and Vandebona, H and Mellick, GD and Mastaglia, F and Stevens, J and Kwok, J and Garlepp, M and Silburn, PA and Horne, MK and Kotschet, K and Venn, A and Rowe, DB and Rubio, JP and Sue, CM, Prevalence and Clinical Features of Common LRRK2 Mutations in Australians with Parkinson's Disease, Movement Disorders, 22, (7) pp. 982-989. ISSN 0885-3185 (2007) [Refereed Article]

DOI: doi:10.1002/mds.21477

Abstract

We determined the prevalence of two common leucine-rich repeat kinase 2 (LRRK2) gene mutations in Australian patients with Parkinson's disease (PD). Of 830 affected patients, eight were heterozygous for the G2019S mutation, and two were heterozygous for the R1441H (4,322 G > A) mutation. In addition, one familial patient had a novel A1442P (4,324 G > C) mutation. Haplotype analysis showed that all LRRK2 G2019S-positive individuals carried the common founder haplotype 1 and a putative founder haplotype for the R1441H mutation carriers. Clinically, patients with LRRK2 mutations had typical levodopa responsive Parkinsonism with tremor being the commonest presenting feature. Patients with the G2019S mutation in our series had a similar age of onset of symptoms when compared with patients with other LRRK2 mutations or sporadic PD, although they were more likely to have a family history of PD (2.4% of Australian patients with familial PD and 0.3% of Australian patients with sporadic PD). Our results demonstrate that the G2019S mutation carriers share the same ancestors who migrated to Australia originally from Europe and that other LRRK2 mutations (R1441H and A1442P) can be found in this population. © 2007 Movement Disorder Society.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Venn, A (Professor Alison Venn)
ID Code:49965
Year Published:2007
Web of Science® Times Cited:27
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2008-05-14
Downloads:0

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