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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework


Calabrese, EJ and Bachmann, KA and Bailer, AJ and Bolger, PM and Borak, J and Cai, L and Cedergreen, N and Cherian, MG and Chiueh, CC and Clarkson, TW and Cook, RR and Diamond, DM and Doolittle, DJ and Dorato, MA and Duke, SO and Feinendegen, L and Gardner, DE and Hart, RW and Hastings, KL and Hayes, AW and Hoffman, GR and Ives, JA and Jaworowski, Z and Johnson, TE and Jonas, WB and Kaminski, NE and Keller, JG and Klaunig, JE and Knudsen, TB and Kozumbo, WJ and Lettieri, T and Liu, S and Maisseu, A and Maynard, KI and Masoro, EJ and McClellan, RO and Mehendale, HM and Mothersill, C and Newlin, DB and Nigg, HN and Oehme, FW and Phalen, RF and Philbert, MA and Rattan, SIS and Riviere, JE and Rodricks, J and Sapolsky, RM and Scott, BR and Seymour, C and Sinclair, DA and Smith-Sonneborn, J and Snow, ET and Spear, L and Stevenson, DE and Thomas, Y and Tubiana, M and Williams, GM and Mattson, MP, Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework, Toxicology and Applied Pharmacology, 222, (1) pp. 122-128. ISSN 0041-008X (2007) [Refereed Article]

DOI: doi:10.1016/j.taap.2007.02.015


Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines. © 2007 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Toxicology (incl. clinical toxicology)
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Snow, ET (Associate Professor Elizabeth Snow)
ID Code:49820
Year Published:2007
Web of Science® Times Cited:467
Deposited By:Health Sciences A
Deposited On:2007-08-01
Last Modified:2009-10-06

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