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The effect of season on cytokine expression in multiple sclerosis and healthy subjects


Stewart, NJ and Taylor, BVM and Ponsonby, AL and Pittas, F and Van der Mei, IAF and Woods, GM and Walters, EH, The effect of season on cytokine expression in multiple sclerosis and healthy subjects, Journal of Neuroimmunology, 188, (1-2) pp. 181-186. ISSN 0165-5728 (2007) [Refereed Article]

DOI: doi:10.1016/j.jneuroim.2007.06.012


We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect. Crown Copyright © 2007.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Stewart, NJ (Dr Niall Stewart)
UTAS Author:Taylor, BVM (Professor Bruce Taylor)
UTAS Author:Ponsonby, AL (Professor Anne Ponsonby)
UTAS Author:Pittas, F (Dr Fotini Pittas)
UTAS Author:Van der Mei, IAF (Professor Ingrid van der Mei)
UTAS Author:Woods, GM (Professor Gregory Woods)
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:49419
Year Published:2007
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2009-08-20

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