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Leber's Hereditary Optic Neuropathy (LHON) Triggered by Antiretroviral Therapy for Human Immunodeficiency Virus (HIV)


Mackey, DA and Fingert, JH and Luzhansky, JZ and McCluskey, PJ and Howell, N and Hall, AJ and Pierce, AB and Hoy, JF, Leber's Hereditary Optic Neuropathy (LHON) Triggered by Antiretroviral Therapy for Human Immunodeficiency Virus (HIV), Eye, 17, (3) pp. 312-317. ISSN 0950-222X (2003) [Refereed Article]

DOI: doi:10.1038/sj.eye.6700362


Purpose. To describe the clinical features of two cases of Leber's hereditary optic neuropathy (LHON) precipitated by antiretroviral treatment for human immunodeficiency virus (HIV) infection. Methods. Two cases of LHON (from an expected four new cases a year throughout Australia) were identified in men on treatment for HIV infection. Results. Two HIV-infected men were receiving combination antiretroviral therapy that included nucleoside analogues. Both patients carried the 14 484 mitochondrial DNA mutation and were distantly related (seventh cousins). Although both men presented with sequential visual loss typical of LHON and one had a known close relative affected by LHON, the correct diagnosis was delayed in both cases. The final visual outcome was profoundly reduced in both instances and cessation of antiretroviral therapy did not result in recovery of vision in one patient. Conclusion. Patients with a family history of LHON who require antiretroviral treatment should be warned of the high risk of severe visual loss. The underlying mechanism of antiretroviral side effects may help characterize the other trigger factors for LHON.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
UTAS Author:Mackey, DA (Professor David Mackey)
UTAS Author:Hall, AJ (Miss Amelia Hall)
ID Code:49033
Year Published:2003
Web of Science® Times Cited:53
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2011-10-04

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