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Metallothionein expression by NG2 glial cells following CNS injury


Chung, RS and Fung, SJ and *Leung, YK and Walker, AK and McCormack, GH and Chuah, MI and Vickers, JC and West, AK, Metallothionein expression by NG2 glial cells following CNS injury, Cellular and Molecular Life Sciences, 64, (19-20) pp. 2716-2722. ISSN 1420-682X (2007) [Refereed Article]

DOI: doi:10.1007/s00018-007-7267-8


Metallothionein (MT) expression is rapidly up-regulated following CNS injury, and there is a strong correlation between the presence or absence of MTand improved or impaired (respectively) recovery from such trauma.We now report that a distinct subset of NG2-positive, GFAP-negative glial cells bordering the injury tract express MT following focal injury to the adult rat neocortex. To confirm the ability of these NG2 glial cells to express MT, we have isolated and cultured them and identified that they can express MT following stimulation with zinc. To investigate the functional importance of MT expression by NG2 glial cells, we plated cortical neurons onto these cells and found that expression of MT enhanced the permissivity of NG2 glial cells to neurite outgrowth. Our data suggest that expression of MT by NG2 glial cells may contribute to the overall permissiveness of these cells to axon regeneration. © 2007 Birkhäuser Verlag.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Chung, RS (Associate Professor Roger Chung)
UTAS Author:Fung, SJ (Miss Samantha Fung)
UTAS Author:*Leung, YK (Dr Jacqueline Leung)
UTAS Author:Walker, AK (Mr Adam Walker)
UTAS Author:McCormack, GH (Mr Graeme McCormack)
UTAS Author:Chuah, MI (Associate Professor Inn Chuah)
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:West, AK (Professor Adrian West)
ID Code:48982
Year Published:2007
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2012-12-12

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