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Oxycodone as a component of multimodal analgesia for lactating mothers after Caesarean section: relationship between maternal plasma, breast milk and neonatal plasma levels
Citation
Seaton, S and Reeves, MD and McLean, SR, Oxycodone as a component of multimodal analgesia for lactating mothers after Caesarean section: relationship between maternal plasma, breast milk and neonatal plasma levels, Australian and New Zealand Journal of Obstetrics and Gynaecology, 47, (3) pp. 181-185. ISSN 0004-8666 (2007) [Refereed Article]
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Copyright Statement
The definitive published version is available online at: http://onlinelibrary.wiley.com/
Official URL: http://onlinelibrary.wiley.com/
DOI: doi:10.1111/j.1479-828X.2007.00715.x
Abstract
Background: Oxycodone has become popular for post-Caesarean section (CS) analgesia yet it is not currently recommended for use in breast-feeding mothers because of limited information on its excretion into breast milk. Aim: To investigate the relationship between maternal ingestion of oxycodone after CS and the resultant maternal plasma, breast milk and neonatal plasma drug levels up to 72-h post-partum. Methods: Fifty breast-feeding mothers taking oxycodone had blood and breast milk samples analysed for oxycodone levels at 24 h intervals after CS. Forty-one neonates had blood samples taken at 48 h. Results: Oxycodone was detected in the milk of mothers who had taken any dose in a 24-h period, with significant correlation between maternal plasma and milk levels (R 2 = 0.81). The median milk:plasma (M:P) ratio for the same period was 3.2:1. Over the subsequent 48 h, the relationship between plasma and milk levels was less strong (R 2 = 0.59) and there was a larger range of M:P levels with evidence of persistence of oxycodone in the breast milk of some mothers. Oxycodone levels up to 168 ng/mL were detected in breast milk (20% > 100 ng/mL). Oxycodone was detected in the plasma of one infant. Conclusions: Oxycodone is concentrated in human breast milk up to 72-h post-partum. Breastfed infants may receive > 10% of a therapeutic infant dose. However, maternal oxycodone intake up to 72-h post-CS poses only minimal risk to the breast-feeding infant as low volumes of breast milk are ingested during this period. © 2007 The Authors Journal compilation © 2007 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Reproductive medicine |
| Research Field: | Obstetrics and gynaecology |
| Objective Division: | Health |
| Objective Group: | Specific population health (excl. Indigenous health) |
| Objective Field: | Neonatal and child health |
| UTAS Author: | Seaton, S (Mrs Suzette Seaton) |
| UTAS Author: | Reeves, MD (Dr Mark Reeves) |
| UTAS Author: | McLean, SR (Professor Stuart McLean) |
| ID Code: | 48980 |
| Year Published: | 2007 |
| Web of Science® Times Cited: | 45 |
| Deposited By: | Pharmacy |
| Deposited On: | 2007-08-01 |
| Last Modified: | 2011-04-27 |
| Downloads: | 0 |
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