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Airway wall remodelling: the influence of corticosteroids

Citation

Ward, C and Walters, EH, Airway wall remodelling: the influence of corticosteroids , Curent Opinion in Allergy and Clinical Immunology, 5, (1) pp. 43-48. ISSN 1528-4050 (2005) [Refereed Article]

DOI: doi:10.1097/00130832-200502000-00009

Abstract

Purpose of the review: We have attempted to bring together recent findings, mainly from airway endobronchial biopsies, on the structural changes that constitute 'remodelling' in airway disease, with a particular focus on asthma. We have tried to put this into the context of classic studies on the asthma pathological phenotype. Having described these basic changes, we have then given an update on recent studies investigating the effects of corticosteroid medication on the different manifestations of remodelled airways. Recent findings: The effects of corticosteroid on airway remodelling seem to vary a great deal; some aspects are steroid responsive while others are not, or less so. It is likely that different manifestations of remodelling require different doses and timescales for treatment to be effective. Summary: Further longitudinal interventional studies are required, with multiple airway sampling times, to fully elucidate the full potential for corticosteroids to benefit remodelling of the airways in chronic inflammatory diseases. There needs to be more attention to pathophysiological and clinical correlations in such studies. It is likely that even when used optimally corticosteroids will have limited efficacy overall in this aspect of asthma pathogenesis. The search is on for newer and better treatments.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Ward, C (Dr Christopher Ward)
Author:Walters, EH (Professor Haydn Walters)
ID Code:48926
Year Published:2005
Web of Science® Times Cited:32
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2012-02-17
Downloads:0

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