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The use of a 'liquid' electrode in hepatic electrolysis


Finch, JG and Fosh, BG and Anthony, AA and Texler, M and Pearson, S and Dennison, AR and Maddern, GJ, The use of a 'liquid' electrode in hepatic electrolysis, Journal of Surgical Research, 120, (2) pp. 272-277. ISSN 0022-4804 (2004) [Refereed Article]

DOI: doi:10.1016/j.jss.2004.03.019


Background The use of direct current electrolysis as a local nonthermal ablative technique for colorectal liver metastases promises to be a simple, safe, and effective therapy. Under general anesthesia, electrolysis is presently limited to tumors smaller than 5 cm, due to the protracted nature of its administration. In an attempt to enhance the effect of electrolysis, a direct current was passed through a preinjected bolus of acetic acid. Methods The effect of a combination of electrolysis and an injection of acetic acid was tested in the liver of eight normal pigs. The volumes of necrosis caused were analyzed. Results Acetic acid independently produced a volume of necrosis but did not provide a volumetric or rate advantage when used in combination with a direct current. Statistically, the only main effect on the volume of necrosis was a result of electrolysis. Conclusion The use of 50% acetic acid to augment the efficacy of direct current electrolysis cannot be recommended. © 2004 Elsevier Inc. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Oncology and carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Pearson, S (Dr Sue Pearson)
ID Code:48884
Year Published:2004
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2011-11-17

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