eCite Digital Repository
Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis
Citation
Warren, MJ and Roddam, LF and Power, PM and Terry, TD and Jennings, MP, Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis, FEMS Immunology and Medical Microbiology, 41, (1) pp. 43-50. ISSN 0928-8244 (2004) [Refereed Article]
DOI: doi:10.1016/j.femsim.2004.01.002
Abstract
Pilin is the major subunit of the essential virulence factor pili and is glycosylated at Ser63. In this study we investigated the gene pglI to determine whether it is involved in the biosynthesis of the pilin-linked glycan of Neisseria meningitidis strain C311#3. A N. meningitidis C311#3pglI mutant resulted in a change of apparent molecular weight in SDS-PAGE and altered binding of antisera, consistent with a role in the biosynthesis of the pilin-linked glycan. These data, in conjunction with homology with well-characterised acyltransferases suggests a specific role for pglI in the biosynthesis of the basal 2,4-diacetamido-2,4,6-trideoxyhexose residue of the pilin-linked glycan. © 2004 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Medical Biochemistry and Metabolomics |
| Research Field: | Medical Biochemistry and Metabolomics not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Infectious Diseases |
| Author: | Roddam, LF (Dr Louise Roddam) |
| ID Code: | 48870 |
| Year Published: | 2004 |
| Web of Science® Times Cited: | 25 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2007-11-05 |
| Last Modified: | 2011-10-04 |
| Downloads: | 0 |
Repository Staff Only: item control page