File(s) not publicly available
Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis
journal contribution
posted on 2023-05-16, 20:30 authored by Warren, MJ, Louise RoddamLouise Roddam, Power, PM, Terry, TD, Jennings, MPPilin is the major subunit of the essential virulence factor pili and is glycosylated at Ser63. In this study we investigated the gene pglI to determine whether it is involved in the biosynthesis of the pilin-linked glycan of Neisseria meningitidis strain C311#3. A N. meningitidis C311#3pglI mutant resulted in a change of apparent molecular weight in SDS-PAGE and altered binding of antisera, consistent with a role in the biosynthesis of the pilin-linked glycan. These data, in conjunction with homology with well-characterised acyltransferases suggests a specific role for pglI in the biosynthesis of the basal 2,4-diacetamido-2,4,6-trideoxyhexose residue of the pilin-linked glycan. © 2004 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
History
Publication title
FEMS Immunology and Medical MicrobiologyVolume
41Pagination
43-50ISSN
0928-8244Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Science BvPlace of publication
Po Box 211, Amsterdam, Netherlands, 1000 AeRepository Status
- Restricted