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Sympathetic nervous control of the cerebral circulation in sleep

Citation

Loos, N and Grant, DA and Wild, J and Gall, SL and Barfield, C and Zoccoli, G and Franzini, C and Walker, AM, Sympathetic nervous control of the cerebral circulation in sleep, Journal of Sleep Research, 14, (3) pp. 275-283. ISSN 0962-1105 (2005) [Refereed Article]

DOI: doi:10.1111/j.1365-2869.2005.00464.x

Abstract

Cerebral vessels are extensively innervated by sympathetic nerves arising from superior cervical ganglia, and these nerves might play a protective role during the large arterial pressure surges of active sleep (AS). We studied lambs (n = 10) undergoing spontaneous sleep-wake cycles before and after bilateral removal of the superior cervical ganglia (SCGx, n = 5) or sham ganglionectomy (n = 5). Lambs were instrumented to record cerebral blood flow (CBF, flow probe on the superior sagittal sinus), carotid arterial pressure (Pca), intra-cranial pressure (Pic), cerebral perfusion pressure (P cp = Pca-Pic) and cerebral vascular resistance (CVR). Prior to SCGx, CBF (mL min-1) was significantly higher in AS than in Quiet Sleep (QS) and Quiet Wakefulness (QW) (17 ± 2, 13 ± 3, and 14 ± 3 respectively, mean ± SD, P < 0.05). Following SCGx, baseline CBF increased by 34, 31, and 29% respectively (P < 0.05). CVR also decreased in all states by ∼25% (P < 0.05). During phasic AS, surges of Pca were associated with transient increases in Pcp, Pic and CBF. Following SCGx, peak CBF and Pic during surges became higher and more prolonged (P < 0.05). Our study is the first to reveal that tonic sympathetic nerve activity (SNA) constricts the cerebral circulation and restrains baseline CBF in sleep. SNA is further incremented during arterial pressure surges of AS, limiting rises in CBF and Pic, possibly by opposing vascular distension as well as by constricting resistance vessels. Thus, SNA may protect cerebral micro vessels from excessive distension during AS, when large arterial blood pressure surges are common. © 2005 European Sleep Research Society.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Gall, SL (Dr Seana Gall)
ID Code:48783
Year Published:2005
Web of Science® Times Cited:16
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-11-02
Last Modified:2011-11-02
Downloads:0

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