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The wound repair response controls outcome to cutaneous leishmaniasis


Sakthianandeswaren, A and Elso, CM and Simpson, K and Curtis, JM and Kumar, B and Speed, TP and Handman, E and Foote, SJ, The wound repair response controls outcome to cutaneous leishmaniasis, Proceedings of the National Academy of Sciences of the United States of America, 102, (43) pp. 15551-15556 . ISSN 0027-8424 (2005) [Refereed Article]

DOI: doi:10.1073/pnas.0505630102


Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1. -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by Leishmania major. Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired in vitro wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis. © 2005 by The National Academy of Sciences of the USA.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Medical genetics (excl. cancer genetics)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Foote, SJ (Professor Simon Foote)
ID Code:48750
Year Published:2005
Web of Science® Times Cited:40
Deposited By:Menzies Institute for Medical Research
Deposited On:2007-08-01
Last Modified:2011-11-03

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