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Mice that are congenic for the char2 locus are susceptible to malaria
journal contribution
posted on 2023-05-16, 20:26 authored by Burt, RA, Marshall, VM, Wagglen, J, Rodda, FR, Senyschen, D, Baldwin, TM, Buckingham, LA, Simon James FooteSimon James FooteA major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.
History
Publication title
Infection and ImmunityVolume
70Issue
8Pagination
4750-4753ISSN
0019-9567Department/School
Menzies Institute for Medical ResearchPublisher
Amer Soc MicrobiologyPlace of publication
1752 N St Nw, Washington, USA, Dc, 20036-2904Repository Status
- Restricted