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An electromyographic analysis of the effect of levodopa on the response time of healthy subjects


Hasbroucq, T and Tandonnet, C and Micallef-Roll, J and Blin, O and Possamai, CA, An electromyographic analysis of the effect of levodopa on the response time of healthy subjects, Psychopharmacology, 165, (3) pp. 313-316. ISSN 0033-3158 (2003) [Refereed Article]

DOI: doi:10.1007/s00213-002-1304-y


Rationale: Recently, we have shown that oral absorption of levodopa shortens reaction time (RT), measured as the interval between the response signal and the onset of voluntary electromyographic (EMG) activity. The motor time (MT) interval that elapses from the EMG activity to the mechanical response was not analysed. Objective: The purpose of the present study was to analyse the effect of the dose of levodopa administrated in our previous study on the MT. Eight healthy adults (aged 21-28, mean=25), performed a two-choice visual RT task after oral absorption of a single dose of levodopa (200 mg) or a placebo (randomized, double-blind, cross-over design). Results: Like RT, MT was shorter under levodopa than under placebo. Statistical analyses demonstrated that this effect was present for all deciles of the RT and MT distributions. Conclusion: Levodopa shortens not only RT but also MT, which points at the implication of the dopaminergic system in both premotor and motor processes.

Item Details

Item Type:Refereed Article
Research Division:Psychology
Research Group:Applied and developmental psychology
Research Field:Educational psychology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Behaviour and health
UTAS Author:Tandonnet, C (Dr Christophe Tandonnet)
ID Code:48254
Year Published:2003
Web of Science® Times Cited:11
Deposited By:Psychology
Deposited On:2007-10-10
Last Modified:2007-10-10

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