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Influences of gender and region on responses to 5-HT in the rat small intestine

Citation

Liu, H and Irving, HR and Tan, YY and Meng, L and Chetty, N and Coupar, IM, Influences of gender and region on responses to 5-HT in the rat small intestine, Pharmacology, 72, (4) pp. 220-224. ISSN 0031-7012 (2004) [Refereed Article]


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Copyright Statement

Copyright 2004 S. Karger AG, Basel

Official URL: http://www.karger.com/

DOI: doi:10.1159/000080376

Abstract

The aim of this study was to obtain more information regarding the 'atypical' 5-HT7 receptor of the rat jejunum. 5-HT 7-induced contractions of the jejunum were elicited by 5-HT in the presence of ondansetron. Maximal responses were slightly larger in tissues from male compared to female rats of comparable age, with Emax values of 97.2 ± 3.3 and 84.25 ± 4.3% respectively compared to acetylcholine as an internal standard. However, the pEC50 values for 5-HT were not significantly different. The mRNA expression levels of the 5-HT7 receptor were similar in whole jejunum and longitudinal muscle tissues taken from males and females. It was also shown that the maximal response of the jejunum from male rats was larger than the responses from mid intestine and ileum. However, in female tissues, the Emax of the mid intestine was significantly larger than the ileum, but not different from the jejunum. The results provide further insights into the 'atypical' 5-HT7 receptor of the rat jejunum and are also useful in optimising the preparation for further studies. Copyright © 2004 S. Karger AG, Basel.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Pharmacology and Pharmaceutical Sciences not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Preventive Medicine
Author:Tan, YY (Dr Yean Tan)
ID Code:47844
Year Published:2004
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2007-08-01
Last Modified:2011-11-24
Downloads:0

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