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Sorbents with immobilized glycopeptide antibiotics for separating optical isomers by high-performance liquid chromatography

journal contribution
posted on 2023-05-16, 20:06 authored by Kuznetsov, MA, Nesterenko, PN, Vasiarov, GG, Staroverov, SM
Chiral sorbents for HPLC separation of optical isomers carrying glycopeptide antibiotics (eremomycin or its eremosaminyl aglycon, ristomycin, or vancomycin) fixed onto the surface of silica gel have been synthesized. The patterns of the retention and separation of profen isomers and their dependence on the nature of the chiral selector and the eluant composition have been studied. The sorbents were shown to be highly enantiospecific in separating the isomers of α-amino-, α-hydroxy-, and α-methylphenylcarboxylic acids (profens). © 2006 Nauka/Interperiodica.

History

Publication title

Applied Biochemistry and Microbiology

Volume

42

Issue

6

Pagination

536-544

ISSN

0003-6838

Department/School

School of Natural Sciences

Publisher

MAIK Nauka - Interperiodica

Place of publication

Russian Federation

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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